abstract：:N-acetylserotonin methyltransferase (ASMT), the last enzyme in the synthesis of melatonin, catalyzes N-acetylserotonin into melatonin. For the first time, we cloned ASMT from rice through the analysis of recombinant Escherichia coli harboring putative rice O-methyltransferase (OMT) cDNAs. In total, 18 full-length cDNA...

journal_title：Journal of pineal research

authors： Kang K,Kong K,Park S,Natsagdorj U,Kim YS,Back K

更新日期：2011-04-01 00:00:00

abstract：:Obesity, a major risk factor for ischemic heart disease, is associated with increased oxidative stress and reduced antioxidant status. Melatonin, a potent free radical scavenger and antioxidant, has powerful cardioprotective effects in lean animals but its efficacy in obesity is unknown. We investigated the effects of...

journal_title：Journal of pineal research

authors： Nduhirabandi F,Du Toit EF,Blackhurst D,Marais D,Lochner A

更新日期：2011-03-01 00:00:00

abstract：:Oxidative stress is reported as one of the most widely accepted mechanisms of maneb (MB)- and paraquat (PQ)-induced nigrostriatal dopaminergic neurodegeneration leading to the Parkinson's disease (PD) phenotype. The study investigated the effects of silymarin, an antioxidant of plant origin, and melatonin, an indoleam...

journal_title：Journal of pineal research

authors： Singhal NK,Srivastava G,Patel DK,Jain SK,Singh MP

更新日期：2011-03-01 00:00:00

abstract：:Doxorubicin (DOX) and Trastuzumab (TRAST) are effective agents for the treatment of many neoplastic diseases. Cardiotoxicity is a major side effect of these drugs and limit their use. In this study, the possible protective effects of melatonin (MEL), mercaptoethylguanidine (MEG), or N-(3-(aminomethyl) benzyl) acetamid...

journal_title：Journal of pineal research

authors： Ozturk M,Ozler M,Kurt YG,Ozturk B,Uysal B,Ersoz N,Yasar M,Demirbas S,Kurt B,Acikel C,Oztas Y,Arpaci F,Topal T,Ozet A,Ataergin S,Kuzhan O,Oter S,Korkmaz A

更新日期：2011-01-01 00:00:00

abstract：:Melatonin is produced following circadian rhythm with high levels being released at night and has been implicated in the regulation of physiological processes in major tissues, including the pancreas. The aim of our study was to examine the effects of melatonin on intracellular free Ca(2+) concentration ([Ca(2+) ](c))...

journal_title：Journal of pineal research

authors： del Castillo-Vaquero A,Salido GM,Gonzalez A

更新日期：2010-10-01 00:00:00

abstract：:Human placental mitochondria might be a significant source of NADPH- and iron-dependent production of reactive oxygen species (ROS). Preeclampsia is believed to be a consequence of overproduction of ROS in human placenta. The experimental results presented here show that melatonin inhibits NADPH- and iron-dependent li...

journal_title：Journal of pineal research

authors： Milczarek R,Hallmann A,Sokołowska E,Kaletha K,Klimek J

更新日期：2010-09-01 00:00:00

abstract：:The effect of melatonin was evaluated on three phosphatidylcholine-based membrane models. Changes in liposome dynamics were monitored by fluorescence, following the response of the probe merocyanine-540, as well as by differential scanning calorimetry (DSC). Langmuir monolayers were investigated using molecular area m...

journal_title：Journal of pineal research

authors： de Lima VR,Caro MS,Munford ML,Desbat B,Dufourc E,Pasa AA,Creczynski-Pasa TB

更新日期：2010-09-01 00:00:00

abstract：:Melatonin is an indoleamine synthesized in the pineal gland, and after its release into the blood, it has an extensive repertoire of biological activities, including antitumoral properties. In this study, we found that melatonin reduced the growth of the human melanoma cells SK-MEL-1. The antiproliferative effect was ...

journal_title：Journal of pineal research

authors： Cabrera J,Negrín G,Estévez F,Loro J,Reiter RJ,Quintana J

更新日期：2010-08-01 00:00:00

abstract：:Melatonin and its precursor, l-tryptophan, have been shown to exert gastroprotective effects in animals, but their influence on the gastric damage by aspirin (ASA) in humans has been sparingly investigated. In this study, we designed to determine the effects of melatonin and l-tryptophan on ASA-induced gastric mucosal...

journal_title：Journal of pineal research

authors： Konturek PC,Konturek SJ,Celinski K,Slomka M,Cichoz-Lach H,Bielanski W,Reiter RJ

更新日期：2010-05-01 00:00:00

abstract：:Urotoxicity is one of the major problems associated with cyclophosphamide (CP) chemotherapy in cancer patients. Melatonin is a potent antioxidant and reduces CP-induced urotoxicity. However, the molecular mechanisms of protection offered by melatonin are not yet clear. The present study investigated the role of nuclea...

journal_title：Journal of pineal research

authors： Tripathi DN,Jena GB

更新日期：2010-05-01 00:00:00

abstract：:5-Methoxycarbonylamino-N-acetyltryptamine (MCA-NAT) has been initially described as a ligand at non MT(1), non MT(2) melatonin binding site (MT3) selective versus MT(1) and MT(2), two membrane melatonin receptors. MCA-NAT activity has been reported by others in different models, in vivo, particularly in the intra-ocul...

journal_title：Journal of pineal research

authors： Vincent L,Cohen W,Delagrange P,Boutin JA,Nosjean O

更新日期：2010-04-01 00:00:00

abstract：:Methamphetamine (METH) is a potent psychostimulant drug that may cause neuronal cell degeneration. The underlying mechanisms of METH-induced neuronal toxicity remains poorly understood. In this study, we investigated an important role of calpain-dependent cascades in methamphetamine-induced toxicity in human dopaminer...

journal_title：Journal of pineal research

authors： Suwanjang W,Phansuwan-Pujito P,Govitrapong P,Chetsawang B

更新日期：2010-03-01 00:00:00

abstract：:Previous research has shown that antioxidant (butylated hydroxyanisole) treatment ameliorates respiratory syncytial virus (RSV)-induced disease and lung inflammation. Melatonin has been reported to exhibit a wide varieties of biological effects, including antioxidant and anti-inflammation, and has no evident toxicity ...

journal_title：Journal of pineal research

authors： Huang SH,Cao XJ,Liu W,Shi XY,Wei W

更新日期：2010-03-01 00:00:00

abstract：:Melatonin protects cells against various types of oxidative stress-induced apoptosis due primarily to its ability to effectively scavenge pathological and disease condition-augmented generation of mitochondrial reactive oxygen species (mROS). Once produced, mROS indiscriminately damage mitochondrial components and mor...

journal_title：Journal of pineal research

authors： Jou MJ,Peng TI,Hsu LF,Jou SB,Reiter RJ,Yang CM,Chiao CC,Lin YF,Chen CC

更新日期：2010-01-01 00:00:00

abstract：:N-[2-(6-methoxyquinazolin-4-yl)-ethyl] acetamide (MQA) is a compound formed from the melatonin metabolite N(1)-acetyl-5-methoxykynuramine (AMK). We followed MQA production in reaction systems containing various putative reaction partners, in the absence and presence of hydrogen peroxide and/or copper(II). Although MQA...

journal_title：Journal of pineal research

authors： Kuesel JT,Hardeland R,Pfoertner H,Aeckerle N

更新日期：2010-01-01 00:00:00

abstract：:Malaria, which infects more than 300 million people annually, is a serious disease. Epidemiological surveys indicate that of those who are affected, malaria will claim the lives of more than one million individuals, mostly children. There is evidence that the synchronous maturation of Plasmodium falciparum, the parasi...

journal_title：Journal of pineal research

authors： Srinivasan V,Spence DW,Moscovitch A,Pandi-Perumal SR,Trakht I,Brown GM,Cardinali DP

更新日期：2010-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers and its incidence is increasing worldwide. Melatonin, an indoleamine hormone, exerts anti-oxidant, immunomodulatory, anti-aging, and antitumor effects. Previous studies have shown that melatonin can act through specific receptors, including MT(1), MT(2),...

journal_title：Journal of pineal research

authors： Carbajo-Pescador S,Martín-Renedo J,García-Palomo A,Tuñón MJ,Mauriz JL,González-Gallego J

更新日期：2009-11-01 00:00:00

abstract：:Sirtuin 1 is a member of the sirtuin family of protein deacetylases, which have attracted considerable attention as mediators of lifespan extension in several model organisms. Induction of sirtuin 1 expression also attenuates neuronal degeneration and death in animal models of Alzheimer's disease and Huntington's dise...

journal_title：Journal of pineal research

authors： Tajes M,Gutierrez-Cuesta J,Ortuño-Sahagun D,Camins A,Pallàs M

更新日期：2009-10-01 00:00:00

abstract：:Previous studies showed that melatonin or dehydroepiandrosterone (DHEA) enhances the immune response against parasitic pathogens. The present study investigated the in vitro activity of melatonin combined with DHEA in a period of 24 hr during the course of in vivo T. cruzi infection. The in vitro activity of melatonin...

journal_title：Journal of pineal research

authors： Kuehn CC,Rodrigues Oliveira LG,Santos CD,Ferreira DS,Alonso Toldo MP,de Albuquerque S,do Prado JC Jr

更新日期：2009-10-01 00:00:00

abstract：:Solid data support the idea that the MT(3) melatonin binding site is an enzyme, quinone reductase 2 (NQO2), rather than a membrane melatonin receptor. However, the melatonin analogue, 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT), reduces intraocular pressure (IOP) via MT(3) melatonin receptors. Therefore, the...

journal_title：Journal of pineal research

authors： Alarma-Estrany P,Crooke A,Pintor J

更新日期：2009-09-01 00:00:00

abstract：:Melatonin is found in a wide variety of plant species. Several investigators have studied the physiological roles of melatonin in plants. However, its role is not well understood because of the limited information on its biosynthetic pathway. To clarify melatonin biosynthesis in plants, we isolated a cDNA-coded arylal...

journal_title：Journal of pineal research

authors： Okazaki M,Higuchi K,Hanawa Y,Shiraiwa Y,Ezura H

更新日期：2009-05-01 00:00:00

abstract：:The purpose of this study was to evaluate the effect of melatonin on oxidative stress occurring in the brain after routine lobectomy neurosurgery procedures. Different concentrations of melatonin (5, 15 and 150 mg/kg) were administered 1 hr before lobectomy in a rodent surgical brain injury (SBI) model. Neurological o...

journal_title：Journal of pineal research

authors： Lee S,Jadhav V,Ayer RE,Rojas H,Hyong A,Lekic T,Tang J,Zhang JH

更新日期：2009-01-01 00:00:00

abstract：:Cell movement is generated by a driving force provided by dynamic cytoskeletal organization. Two main cytoskeletal-dependent features, essential for migration, are the highly cell polarized structure and focal adhesion complexes. Cell migration and substrate anchorage are finely regulated by external signaling exerted...

journal_title：Journal of pineal research

authors： Ortíz-López L,Morales-Mulia S,Ramírez-Rodríguez G,Benítez-King G

更新日期：2009-01-01 00:00:00

abstract：:In this study, the effect of melatonin on sodium arsenite (arsenite)-induced peripheral neurotoxicity was investigated using dorsal root ganglion (DRG) explants. After 24-hr incubation, arsenite (30 microm) consistently elevated the expression of heat shock protein 70 and haeme oxygenase-1, two well-known stress prote...

journal_title：Journal of pineal research

authors： Lin AM,Feng SF,Chao PL,Yang CH

更新日期：2009-01-01 00:00:00

abstract：:N-nitrosomelatonin (NOMela) is well-known for its capabilities of transnitrosating nucleophiles such as thiols and ascorbate, thereby generating nitric oxide (NO)-releasing compounds. It is unknown, however, whether NOMela can be successfully applied as a precursor of NO in a complex biological environment like a cell...

journal_title：Journal of pineal research

authors： Berchner-Pfannschmidt U,Tug S,Trinidad B,Becker M,Oehme F,Flamme I,Fandrey J,Kirsch M

更新日期：2008-11-01 00:00:00

abstract：:In the mammalian pineal gland, the rhythm in melatonin biosynthesis depends on the norepinephrine (NE)-driven regulation of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme of melatonin biosynthesis. A recent study showed that phytocannabinoids like tetrahydrocannabinol reduce AANAT activity and atte...

journal_title：Journal of pineal research

authors： Koch M,Habazettl I,Dehghani F,Korf HW

更新日期：2008-11-01 00:00:00

abstract：:Senescence-accelerated mice (SAMP8) and senescence-accelerated resistant mice (SAMR1) were studied at 5 and 10 months of age, respectively. In the animals, neurodegenerative processes and how they were influenced by melatonin were examined. Melatonin (10 mg/kg) or vehicle (ethanol at 0.066%) treatments were administra...

journal_title：Journal of pineal research

authors： Caballero B,Vega-Naredo I,Sierra V,Huidobro-Fernández C,Soria-Valles C,De Gonzalo-Calvo D,Tolivia D,Gutierrez-Cuesta J,Pallas M,Camins A,Rodríguez-Colunga MJ,Coto-Montes A

更新日期：2008-10-01 00:00:00

abstract：:The role of antioxidants in reducing cancer initiation and progression has been highlighted in recent years. Not only antioxidants limit cancer cell growth but also, in some situations, they promote the effectiveness of conventional treatments. Melatonin, an endogenously synthesized antioxidant, reduces cell growth of...

journal_title：Journal of pineal research

authors： Sainz RM,Reiter RJ,Tan DX,Roldan F,Natarajan M,Quiros I,Hevia D,Rodriguez C,Mayo JC

更新日期：2008-10-01 00:00:00

abstract：:Melatonin, the main secretary product of the pineal gland, is potentially effective in the prevention of a number of diseases in which free radical processes are involved. The development of hypercholesterolemia is a multifactorial process in which elevated oxidized low-density lipoprotein (ox-LDL) levels play a centr...

journal_title：Journal of pineal research

authors： Zhu HQ,Cheng XW,Xiao LL,Jiang ZK,Zhou Q,Gui SY,Wei W,Wang Y

更新日期：2008-10-01 00:00:00

abstract：:The aim of this study was to evaluate the effect of the topical application of melatonin on osteointegration of dental implants in Beagle dogs 14 days after their insertion. In preparation for subsequent insertion of dental implants, upper and lower premolars and molars were extracted from 12 Beagle dogs. Each mandibl...

journal_title：Journal of pineal research

authors： Cutando A,Gómez-Moreno G,Arana C,Muñoz F,Lopez-Peña M,Stephenson J,Reiter RJ

更新日期：2008-09-01 00:00:00

abstract：:Melatonin, which is contained in certain vegetables, may have an influence on circulatory melatonin concentrations. This study examined the effects of the consumption of vegetables on 6-sulfatoxymelatonin concentrations in morning urine. Ninety-four healthy women aged 24-55 were recruited through a city public health ...

journal_title：Journal of pineal research

authors： Oba S,Nakamura K,Sahashi Y,Hattori A,Nagata C

更新日期：2008-08-01 00:00:00

abstract：:Melatonin, a molecule produced in the pineal gland and retina of vertebrates, plays a major role in day-night circadian rhythms and other physiological processes, including the immune responses. Because little is known in this respect in fish, we have evaluated the in vivo role of melatonin in the main innate immune a...

journal_title：Journal of pineal research

authors： Cuesta A,Cerezuela R,Esteban MA,Meseguer J

更新日期：2008-08-01 00:00:00

abstract：:Irradiation of the melatonin metabolite N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) with UV light of 254 nm causes the release of carbon monoxide (CO) and, thus, deformylation to N(1)-acetyl-5-methoxykynuramine (AMK). Liberation of CO was demonstrated by reduction of PdCl(2) to metallic palladium, under avoidan...

journal_title：Journal of pineal research

authors： Seever K,Hardeland R

更新日期：2008-05-01 00:00:00

abstract：:When organic compounds are irradiated with UV light at 254 nm, part of their covalent bonds can dissociate if the compound absorbs light at that wavelength. Therefore, photo-degradation depends strongly on the wavelength used. The energy of a light quanta at 254 nm amounts to approximately 110 kcal/mol quanta, which i...

journal_title：Journal of pineal research

authors： Brömme HJ,Peschke E,Israel G

更新日期：2008-05-01 00:00:00

abstract：:Impaired Ca2+ homeostasis and smooth muscle contractility co-exist in acute cholecystitis (AC) leading to gallbladder dysfunction. There is no pharmacological treatment for this pathological condition. Our aim was to evaluate the effects of melatonin treatment on Ca2+ signaling pathways and contractility altered by ch...

journal_title：Journal of pineal research

authors： Gomez-Pinilla PJ,Camello PJ,Pozo MJ

更新日期：2008-04-01 00:00:00

abstract：:Chronic hyperhomocysteinemia is a risk factor in cardiovascular diseases and neurodegeneration. Among the putative mechanisms of homocysteine-induced neurotoxicity, an increased production of reactive oxygen species has been suggested. However, elevated homocysteine levels might disturb neurogenesis during brain devel...

journal_title：Journal of pineal research

authors： Baydas G,Koz ST,Tuzcu M,Nedzvetsky VS

更新日期：2008-03-01 00:00:00

abstract：:Elevated levels of soluble cellular adhesion molecules have been reported in patients with acute coronary syndromes. Likewise, a relation between decreased nocturnal melatonin levels and coronary artery disease has been suggested. The aim of the present study was to investigate the day-night variations in the concentr...

journal_title：Journal of pineal research

authors： Dominguez-Rodriguez A,Abreu-Gonzalez P,Garcia-Gonzalez MJ,Samimi-Fard S,Kaski JC,Reiter RJ

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to compare the circadian control of melatonin production in teleosts. To do so, the effects of ophthalmectomy on circulating melatonin rhythms were studied along with ex vivo pineal culture in six different teleosts. Results strongly suggested that the circadian control of melatonin productio...

journal_title：Journal of pineal research

authors： Migaud H,Davie A,Martinez Chavez CC,Al-Khamees S

更新日期：2007-11-01 00:00:00

abstract：:Classical anticancer therapies often are ineffective in patients with malignant glioma who have a survival of <1 year. Our previous studies showed a potent inhibitory effect of melatonin on glioma cell proliferation. This effect seems to be mediated by the well-known antioxidant properties of this molecule and the neg...

journal_title：Journal of pineal research

authors： Martín V,Herrera F,García-Santos G,Antolín I,Rodriguez-Blanco J,Medina M,Rodriguez C

更新日期：2007-10-01 00:00:00

abstract：:Melatonin possesses a number of important biologic activities including oncostatic, anti-oxidant, and immunostimulatory actions. This study was designed to assess the effects of melatonin on inflammation-related gene expression in lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs), us...

journal_title：Journal of pineal research

authors： Park HJ,Kim HJ,Ra J,Hong SJ,Baik HH,Park HK,Yim SV,Nah SS,Cho JJ,Chung JH

更新日期：2007-09-01 00:00:00